The best advice I have ever been given was not for my game of choice. But my roll of choice as a Gamemaster. That lovely piece of advice was.
Run the games you enjoy, and tell the stories you would want to be in. Playing RPGs is a hobby and it’s fun and if your not having fun then stop!
This is vice enlighten me to run games for me and my friends that I was comfortable with. And to not try to force myself to run games for my friends that they wanted me to run but I wasn’t capable of running.
Several times sadly I’ve been asked to run animal anthropomorphic games such as Red Wall. But sadly for some reason as a GM, I just can’t wrap my head around the style of stories. Instead of forcing myself to run these games I’ve just politely declined.
Oh, I know that I’m completely capable of running a game like this. The problem is with such a game I would be a struggle. finding a story that I would enjoy telling would be a struggle for me. I think it would also show at the table how hard of a time I would have with the subject. That would take away from my player’s enjoyment of the game.
Runkle Plays Games 
I totally agree with you when it comes to struggling to run games that are just not on your wave length. I almost never play a non human character because I struggle to think and behave at the table the way I think an elf would think. (If I got that the right way around with all the ‘thinking’). So I won’t even play a character I am not comfortable with let alone run a whole game.
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